Situation: Carl returns to Los Santos and is confronted by corrupt C.R.A.S.H. This section of the story is where you will receive some of the most important benefits/unlocks. These missions slowly introduce you to the essentials of the game and the main characters you will encounter many times throughout the story. There are 27 missions in the main thread in Los Santos, including an introductory mini-game mission which leads the player to the first official mission. Many of these missions have Carl as the driver with additional help as required. Missions in this city involve Carl's attempt to regain respect within the Grove Street Families and face the obstacles confronting his family. Protagonist Carl 'CJ' Johnson returns to his hometown of Los Santos and needs to re-establish himself in his former neighborhood. The video ends directly at the beginning of GTA San Andreas, when protagonist Carl 'CJ' Johnson arrives in San Andreas after hearing the news that his mom has died. It was available with the North American PS2 Special Edition of GTA San Andreas or the official soundtrack double CD.

The Introduction is a roughly twenty minute video, created with Grand Theft Auto: San Andreas' video engine, that details how events in Grand Theft Auto: Vice City led to events in Grand Theft Auto: San Andreas.

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